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抗体偶联药物(antibody drug conjugates ，ADCs)是单克隆抗体与抗肿瘤毒性小分子的偶联产物。
ADCs药物主要由三个部分组成：负责选择性识别和靶向肿瘤的抗体（antibody），有效载荷（payload，目前常为小分子细胞毒药物cytotoxin），以及连接抗体与有效载荷的连接子(linker)。化药小分子通过连接子Linker与抗体进行偶联。连接子的稳定性对于ADCs药物的药效影响较大，也是ADCs药物设计的技术难点和评价指标之一。一般而言，ADCs药物依靠抗体对肿瘤细胞相关抗原的特异性，靶向性结合 肿瘤细胞，并且通过内吞作用进入该细胞，连接子在细胞内受到低pH值或溶酶体酶促反应等作用下断裂，释放出有效载荷，从而导致肿瘤细胞死亡。
| 产品编号 | 结构式 | 项目名称规格 | 分子式 | 加入购物车 |
|---|---|---|---|---|
| C839191 |
| 4-羟基环辛烯, 98% Cyclooct-4-enol, 98% |
C8H14O | |
| M821890 |
| 6-马来酰亚胺基己酸, 98% 6-Maleimidocaproic acid, 98% |
C10H13NO4 | |
| D914306 |
| 11,12-二脱氢-γ-氧代二苯并[b,f ]吖辛因-5(6H)-丁酸, 98% DBCO-Acid, 98% |
C19H15NO3 | |
| M824596 |
| 6-(马来酰亚胺基)己酸琥珀酰亚胺酯, 98% 6-Maleimidohexanoic acid N-hydroxysuccinimide ester, 98% |
C14H16N2O6 | |
| M824069 |
| 4-(N-马来酰亚胺基甲基)环己烷-1-羧酸琥珀酰亚胺酯, 98% 4-(Maleimidomethyl)cyclohexane-1-carboxylic acid N-hydroxysuccinimide ester, 98% |
C16H18N2O6 | |
| V868638 |
| (S)-2-[(S)-2-氨基-3-甲基丁酰胺基]-N-[4-(羟甲基)苯基]-5-脲戊酰胺, 98% Val-Cit-PAB-OH, 98% |
C18H29N5O4 | |
| A905353 |
| 4-[(5-氮杂-3,4:7,8-二苯并环辛-1-炔)-5-基]-4-氧代丁酸-N-琥珀酰亚胺酯, 98% 4-[(5-aza-3,4:7,8-dibenzocyclooctan-1-yne)-5-yl]-4-oxobutyrate-n-succinimide, 98% |
C23H18N2O5 | |
| M881874 |
| MC-Val-Cit-PAB , 98% MC-Val-Cit-PAB , 98% |
C28H40N6O7 | |
| R868812 |
| (1R,8S,9s)-双环[6.1.0]壬-4-炔-9-基甲醇, 90% (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethanol, 90% |
C10H14O | |
| M931609 |
| 2-(4-(6-甲基-1,2,4,5-四嗪-3-基)苯基)乙酸, 95% Methyltetrazine-acid, 95% |
C11H10N4O2 | |
| N855016 |
| 4-甲酰苯甲酸 N-琥珀酰亚胺酯, 99% N-Succinimidyl 4-Formylbenzoate, 99% |
C12H9NO5 | |
| E921312 |
| (E)-碳酸环辛-4-烯基2,5-二氧杂-1-吡咯烷基酯, 95% (E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate, 95% |
C13H17NO5 | |
| D914270 |
| 氮杂二苯并环辛炔胺, 95% Dibenzocyclooctyne-aMine, 95% |
C18H16N2O | |
| R868433 |
| (1R,8S,9s)-双环[6.1.0]壬-4-炔-9-基甲基琥珀酰亚胺碳酸酯, ≥90% (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl Succinimidyl Carbonate, ≥90% |
C15H17NO5 | |
| P838450 |
| 3-(2-吡啶基二硫基)丙酸N-羟基琥珀亚酰胺酯, ≥95% 3-(2-Pyridyldithio)propionic Acid N-Succinimidyl Ester, ≥95% |
C12H12N2O4S2 | |
| R937202 |
| rel-((1R,8S,9s)-二环[6.1.0]壬-4-炔-9-基)甲基 4-硝基苯基碳酸酯, 95% rel-((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (4-nitrophenyl) carbonate, 95% |
C17H17NO5 | |
| M864027 |
| Maleimide-PEG2-succinimidyl ester, 99% Maleimide-PEG2-succinimidyl ester, 99% |
C18H23N3O9 | |
| C805398 |
| 6-羧基荧光素琥珀酰亚胺酯, 90% 6-Carboxyfluorescein N-hydroxysuccinimide ester, 90% |
C25H15NO9 | |
| B946162 |
| ((S)-1-(((S)-1-((4-(羟甲基)苯基)氨基)-1-氧代-5-脲基戊-2-基)氨基)-3-甲基-1-氧代丁-2-基)氨基甲酸叔丁酯, 97% Boc-Val-Cit-PABA, 97% |
C23H37N5O6 | |
| T933458 |
| TCO-PEG4-NHS ester, 95% TCO-PEG4-NHS ester, 95% |
C24H38N2O10 |
