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| 别名: | |||
|---|---|---|---|
| Cas号: | 13616-29-0 | 物化性质: | |
| 分子式: | C23H22N8O5S2 | 熔点: | |
| 分子量: | 554.60 | 沸点: | |
| EINECS编号: | 密度: | ||
| MDL号: | 储存条件: | 2-8°C | |
| 技术规格说明书 | |||
| 货号 | 规格 | 可用库存 | 销售价(RMB) | 您的折扣价(RMB) | 数量 | 加入购物车 |
|---|---|---|---|---|---|---|
| N920957-5mg | ≥98% (HPLC) | 预计交期：8~10个工作日 | 1,332.00 | 加入购物车 |
| 用途: | GSK837149A is the first selective inhibitor of human fatty acid synthase (FAS) known to act specifically and selectively on the KR activity of the enzyme. It was first isolated as a minor impurity in a sample found to be active against the enzyme in a high-throughput screening campaign. This compound and its analogs synthesized, all being symmetrical structures containing a bisulfonamide urea, act by inhibiting the beta-ketoacyl reductase activity of the enzyme. GSK837149A inhibits FAS in a reversible mode, with a Ki value of approximately 30 nm, and it possibly binds to the enzyme-ketoacyl-ACP complex. Although initial results suggest that cell penetration for these compounds is impaired, they still can be regarded as useful tools with which to probe and explore the beta-ketoacyl reductase active site in FAS, helping in the design of new inhibitors. |
|---|---|
| 储存条件: | 2-8°C |
| 颜色: | 固体 |
